In spite of introduction of new generations of antiepileptic drugs, management of drug resistant epilepsy is still an unsolved issue. Therefore, we need an entirely new approach to the problem of lack of desired therapeutic effect in epilepsy, particularly when consecutive multidrug regimen proves ineffective. As some children respond favourably to ketogenic diet, the author suggests its use in adult patients too. Furthermore, legitimacy of this therapeutic modality has been confirmed by rigorous trials performed in this age group. Spectrum of possible applications of immunoglobulins in medicine, including neurology, is expanding continuously. Formerly, immunoglobulins were recommended in children with chronic epilepsy and concomitant immune deficit. Reduction of seizure frequency of after administration of immunoglobulins has been observed. Research has also focused on calcium channel blockers, as they may play a role in the pathogenesis of some types of seizures. Verapamil as added drug may also reduce the severity of seizures. Other blockers do not have such properties, but possible effects of vinpocetine are noteworthy. Statins are another important group of drugs contributing to reduction of seizures, particularly atorvastatin. Its antiepileptic effect is independent of cholesterol level reduction.As an adjuvant drug, it is often recommended in the elderly. To sum up, in properly managed drug resistant epilepsy, implementation of one of these treatment options should be considered.

drug-resistant epilepsy, ketogenic diet, immunoglobulins, calcium channel blockers, statin