Ischaemic stroke as a complication of acute coronary syndrome occurs in approximately 1.40% of cases. Multimodal rehabilitation is an essential component of treatment following a stroke. Case report: The clinical case refers to a patient after a stroke and acute coronary syndrome preceded by bilateral leg amputation. This paper presents the course of the 25-day psychomotor rehabilitation programme conducted in the department of neurological rehabilitation. Methods: The treatment has been evaluated using functional scales (Activity Daily Living Scale, Modified Rankin Scale, National Institutes of Health Stroke Scale, Rivermead Motor Assessment) and psychological tests (Geriatric Depression Scale, Mini–Mental State Examination). Results: The functional improvement focused mainly on the upper limb and global movements. The intensity of the depressive disorders decreased from severe to mild (21 versus 11). Mini–Mental State Examination results normalized (19 versus 27). Conclusions: Early-applied individual rehabilitation program with intensive psychological therapy is a very important element of treatment of patients with a multifactorial mobility decrease.